As advised from time to time, drinking a glass of warm milk at bedtime will promote a good night’s rest. Why over here
Milk’s sleep-enhancing properties are usually attributed to tryptophan, but scientists have also discovered a mixture of milk peptides, called casein tryptic hydrolyzate (CTH), which relieves stress and induces sleep. Increases.
Now, researchers reporting in the American Chemical Society’s Journal of Agricultural and Food Chemistry have identified specific peptides in CTH that may someday be used in new, natural sleep remedies.
According to the US Centers for Disease Control and Prevention, one-third of American adults do not get enough sleep. Sedatives, such as benzodiazepines and zolpidem, are commonly prescribed for insomnia, but they can cause side effects, and people can become addicted to them. Many sedatives work by activating the GABA receptor, a protein in the brain that suppresses nerve signaling.
Scientists have also discovered several natural peptides, or small fragments of proteins, that bind to the GABA receptor and have anti-anxiety and sleep-enhancing effects. For example, treatment of a protein called casein in cow’s milk with the digestive enzyme trypsin produces a mixture of sleep-enhancing peptides called CTH.
Within this mixture, a specific peptide known as a-cassoazepine (a-CZP) has been identified that may be responsible for some of these effects. Lin Zheng, Mouming Zhao and their colleagues wondered whether they could find other, perhaps more potent, sleep-enhancing peptides in CTH.
The researchers first compared the effects of CTH and a-CZP in a mouse sleep test, finding that CTH showed better sleep-enhancing properties than a-CZP alone. This result suggested that there are other sleep-promoting peptides present in CTH in addition to a-CZP.
The team then used mass spectrometry to identify the bioactive peptides released from CTH during simulated gastric digestion, and they actually examined these peptides for their ability to bind to the GABA receptor and cross the blood-brain barrier. Of.
When the strongest candidates were tested in rats, the best (YPVEPF) increased the number of rats that fell asleep by about 25 percent faster than a control group and increased sleep duration by more than 400 percent. In addition to this promising peptide, there are others to be explored in CTH that may enhance sleep through other pathways, the researchers say.
The authors acknowledge funding from the National Natural Science Foundation of China, the Guangdong Provincial Key R&D Program, the Shandong Provincial Key R&D Program, and the Specialized Fund Program for Basic and Applied Basic Research of Guangdong Province.
This story has been published without modification in text from a wire agency feed. Only the title has been changed.